Rakel, D. Integrative Medicine, 3rd edition, Saunders, 2012. Dr. Eric L. Zielinski is a sought-after natural . Based on another study of 6 trained and 7 untrained people, an antioxidant combination product containing Pycnogenol (Lactaway) may increase endurance. Proper nutrition is essential for ADHD treatment. In mice, luteolin prevented inflammation and allergic response in the lungs and nose by inhibiting inflammatory cytokines: IL-4, IL-5, and IL-1 3 []. WebMD does not provide medical advice, diagnosis or treatment. Your email address will not be published. Pycnogenol was gradually increased to 120 mg/day over this time period, while the l-arginine was maintained at 1.7 g/day throughout. Ana received her MS in Pharmacy from the University of Belgrade. Pycnogenol in metabolic syndrome and related disorders [Abstract]. Note that the numbers in parentheses (1, 2, etc.) The Benefits of DIM. In a study of 100 healthy women mostly in their early 40s with mild sexual dysfunction, a combination product with Pycnogenol (Lady Prelox) improved sexual function over 8 weeks [74]. (4). High-dose Pycnogenol (360 mg/day) for 4 weeks had the same LDL-lowering benefits in another study of 40 people [32, 56]. All rights reserved. For allergies: 50 milligrams twice daily. Pycnogenol (100 mg/day) may reduce leg swelling, spider veins, and cramps according to a study of 133 women with varicose veins who recently gave birth. Headaches. The women taking Pycnogenol also experienced improvement in fatigue, sleep, concentration, memory, dizziness, and mood, including less irritability. Additionally, the results showed that the extract has significant anti-pseudomonas activity, making it a potential natural remedy and possible preventive measure for infections. In patients with chronic venous insufficiency, the number of muscle cramps decreased from 6.3 to 2.6; in athletes from 8.6 to 2.4. It is chronic venous insufficiency, a common disease among people who are obese or elderly and those who lead a sedentary lifestyle. Seems like it must be pretty amazing, but lets look closer. Here are some basic guidelines as reported by WebMD: While most studies do not indicate major side effects, pine bark extract may cause irritability and fatigue, and could interact with other drugs. Prunes and prune juice have many health benefits. In a double-blind, placebo-controlled, randomized, crossover study, 50 patients with erectile dysfunction (ED) were treated with either L-arginine plus Pycnogenol or placebo for a month. You may want to start slow, taking smaller amounts, to ensure that your body works well with the OPCs found in pine bark extract. (8). They also had normalized fasting glucose levels and blood pressure, which can also reduce a persons risk of heart problems. A number of clinical trials suggest that Pycnogenol may lower blood glucose if taken daily for at least 12 weeks. which enables users to obtain detailed information and reports based on their genome. This supplement possibly activates the immune system. (2013). In a good-quality study, 100 patients with osteoarthritis of the knee were treated for three months either with 150 mg of Pycnogenol a day or placebo. Pycnogenol (up to 200 mg/day) may improve asthma and reduce inflammatory asthma markers in the blood, leukotrienes, after 4 weeks, according to a randomized placebo-controlled trial of 26 asthma patients [14]. Joe Cohen flipped the script on conventional and alternative medicine and it worked. Frustrated by the lack of good information and tools, Joe decided to embark on a learning journey to decode his DNA and track his biomarkers in search of better health. There is insufficient evidence to support the use of Pycnogenol for any of the uses listed below. When pycnogenol cream was added to oral supplements in a small study of 18 people with vein ulcers, it helped ulcers heal more quickly [26]. A study of 66 healthy adults found that Pycnogenol may reduce the number of leg cramps experienced [11]. Some of the top lutein-rich foods to include in your diet are dark leafy greens like spinach and kale, broccoli . (5). Also, be sure to talk with your doctor first if you have an underlying medical condition or take other medications. View as: Grid List. (3), Ototoxicity is ear poisoning and can occur when exposed to certain drugs or chemicals, such as cisplatin, that damage the inner ear or the vestibulocochlear nerve. In those treated with Pycnogenol, the edema score was increased by 17.9% versus an increase of 58.3% in the control group. Diindolylmethane, or DIM for short, is a plant indolea plant compound with health-promoting properties. Pycnogenol treatment reduced the need for painkillers by 58% versus one percent in the placebo-treated group. A systematic review of 14 studies found that Pycnogenol gum or mouthwashes may reduce dental plaque, but the quality of evidence is low [58, 59]. New research shows . As a skin powder, however, you can use it safely for up to six weeks. However, in all the above studies insulin levels did not change. If possible, try to get pine bark extract from a local supplier, such as a health food store. A trial of children with ADHD found that Pycnogenol may improve attention, possibly by increasing the total antioxidant status and reducing DNA damage. Pycnogenol also potentially improved cognitive function in 78 people with mild cognitive impairment. A Pycnogenol combination product (with l-arginine, alpha lipoic acid, B vitamins, and vitamin K2) may help protect the blood vessels and reduce high homocysteine levels, according to a trial of 25 people [39]. We all know the power of antioxidants to improve health and thehigh-antioxidant foodswe should eat regularly. Remember to speak with a doctor before taking Pycnogenol. - Please read carefully and implement principles included in the Health Recovery Plan. 10 Day Erection Delay Sex Pills. If you are thinking of taking Pycnogenol for a serious health condition like asthma or high blood pressure, check with your doctor., People who have autoimmune conditions like multiple sclerosis or lupus should talk to their doctor before trying Pycnogenol. Pycnogenol significantly improved the heavy feeling as well as the swelling. Today's Dietitian: "Pycnogenol Supplement Offers Promise for Managing a Variety of Conditions." Most have similar amounts of active substances and are often sold under the brand name Pycnogenol [6]. Another group of men who took just l-arginine didnt improve [66]. Patients were given 100 milligrams of Pycnogenol, a branded version of pine bark extract, for 12 weeks, with continued anti-diabetic treatment. 11 Skin elasticity increased, and skin fatigue decreased significantly in this study as well, further lowering the wrinkling risk. Erythritol: Is This Healthy Sweetener the Real Deal? but is for informational and educational purposes alone. She loves communicating science and empowering people to achieve their optimal health. While OPCs found in this extract are mostly known for their antioxidant-producing benefits, these amazing compounds exude antibacterial, antiviral, anticarcinogenic, anti-aging, anti-inflammatory and anti-allergic properties. Additionally, athletes have endured less cramping and muscle pain when using the extract. Interactions. Masquelier was easily able to create a pine bark extract from materials that were otherwise known as waste. The specific tree from which the bark is extracted is called a maritime pine. Extracts can also be made from other pine barks, such as Pinus radiata, Pinus densiflora, Pinus thunbergii, and Pinus massoniana. Researchers suggest that it may epigenetically turn off genes responsible for joint damage (ADAMTS) as well as reduce inflammation enzymes (MMP3) and cytokines (IL 1-beta) [47, 48]. As noted, aspirin can cause severe gastrointestinal issues. All of our content is written by scientists and people with a strong science background. However, with the addition of twice-daily Pycnogenol, normal erection increased to 80%, which further increased to 92.5% during the third month on thrice-daily Pycnogenol. Two studies illustrate the possibilities: One was a randomized, double-blind, placebo-controlled, crossover study in which 26 asthmatic patients were given either a maximum of 200 mg a day of Pycnogenol or placebo for the first period of four weeks and then crossed over to the alternate treatment for the next four weeks. ", Mayo Clinic: High blood pressure (hypertension)., Panminerva Medica: "Pycnogenol improvements in asthma management. Thirty patients were treated with 150 mg of Pycnogenol a day and the other 10 patients with placebo for a period of two months. Twenty-one patients were given Pycnogenol at 150 mg daily and 18 patients received no treatment for a period of eight weeks. 2. For improving exercise capacity in athletes: 200 milligrams daily. It also may help regenerate and maintain vitamin C and E levels while also potentially increasing nitric oxide levels, which may relax and protect blood vessels [1]. Healthline Media does not provide medical advice, diagnosis, or treatment. Blood pressure is an important measure of how much blood is pumping from your heart to the rest of your body . According to a study of 11 patients with lupus, pycnogenol may reduce symptoms, inflammation, and oxidative stress [54]. A study of 50 mildly infertile men found that a combination of L-arginine, L-citrulline, roburins, and Pycnogenol (Prelox R) may improve sperm quality, volume, and concentration [75]. While much of this is positive, it will be a while before doctors routinely recommend this dietary supplement for these conditions. A small 2012 study on postmenopausal women found that pine bark extract improved hydration and elasticity of skin. Pycnogenol is a compound of natural chemicals. This plant extract also shows promise in such far-flung conditions as traumatic brain injury 40,41, skin problems 37, pain syndromes 38,39, and even tinnitus . We avoid using tertiary references. With time, the participants were able to handle more UV radiation without experiencing skin damage [63]. In another good study, 48 patients with diabetes and high blood pressure on ACE inhibitors were randomized to receive either Pycnogenol 125 mg daily or placebo for 12 weeks. Pine bark extract may be the perfect treatment since its an antioxidant dynamo. Learn about this tree-based pill and how it might be able to help you. Improve cardiovascular health. 40 years of research has been dedicated to establishing the safety of Pycnogenol and its benefits for human health. While it may seem intimidating at first, counting macros is a common Erythritol is now one of the most popular natural zero-calorie sweeteners available. In the Pycnogenol-treated group, blood sugar levels were significantly lowered as compared to those not on Pycnogenol. According to the National Institutes of Health, its safe for adults to take 50 to 450 milligrams of pine bark extract daily for up to one year. Eighty-six patients were treated either with Pycnogenol at 150 mg or 300 mg daily or the drugs diosmin and hesperidin (Daflon)at 1,000 mg daily for two months. It can also be found as creams, lotions or ointments, typically containing 0.5 percent to 2 percent pine bark extract. Pycnogenol (100 mg/day) may reduce hay fever symptoms, according to a clinical trial of 39 people. By clicking Subscribe, I agree to the WebMD, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox, Becoming a Vegetarian: Foods to Choose From. While these results are promising, there isnt enough research to fully understand the effect of antioxidant levels on ADHD symptoms. There have been a variety of health benefits linked to beta glucan, specifically with the beta-1 3d glucan form which has more biological activity than other types of polysaccharides. The effects of the pine bark extract showed significant lower levels of blood glucose and improved endothelial function when compared to placebo, concluding that supplementation of Pycnogenol for treating conventional diabetes may be beneficial. First and foremost, start eating an anti-inflammatory Local Raw Honey (Bee Pollen) Considering how good it tastes, having some raw honey Apple Cider Vinegar (ACV) You can now find high-quality apple cider vinegar in . Its been noted that taking OPCs and vitamin C supplements at the same time could increase blood pressure if you have hypertension. Its best to check with your doctor about the dosage, based on the symptoms you have and other possible conditions, prior to taking either pine bark extract or Pycnogenol. It decreased concussion symptoms in 42 student-athletes with a history of sports-related concussions after 6 weeks. Eliminate blood clots. DOI: Scheff SW, et al. A randomized, double-blind, placebo-controlled study of 60 patients aged six to 18 years old, was conducted over three months during which patients were randomly assigned to receive either Pycnogenol or placebo. Researchers suggest it may boost sustained attention, memory, executive functions, mood, and reduce oxidative stress [19]. Symptoms of menopausal syndrome, also known as climacteric syndrome, include: hot flashes; chills; headache; and depression. According to researchers, it may help prevent the rise in free radicals typically seen after exercise, which could cause muscle fatigue and damage [9]. Unlike drug manufacturers, the makers of supplements dont have to show their products are safe or effective before selling them on the market. It can also stabilize mast cells, which release histamine and trigger allergic reactions. This can cause pain, especially in areas of the body that are used repeatedly, like your hands, fingers, and knees. Ginkgo biloba has been widely cultivated across the globe for a variety of uses, most of which are medicinal. 1. A randomized placebo-controlled trial of 60 children with mild-to-moderate asthma found that those who took Pycnogenol may be able to reduce or discontinue their use of rescue inhalers more often than the placebo group [15]. A randomized clinical trial of 30 people found that Pycnogenol (150 mg/day) may help heal vein ulcers from surgery and reduce swelling after 3 months of treatment [25]. During week, five without, treatment, reduction of cramps was maintained in all three groups. , Improves Symptoms Associated With Menopause, A number of women experience physical discomfort due to symptoms of menopause. Along with the rest of the crew, he developed symptoms of vitamin-C deficiency. The U.S. Food and Drug Administration (FDA) does regulate dietary supplements; however, it treats them like foods rather than medications. 7. But did you know that pine bark extract, like pine oil, is one of natures super antioxidants? A clinical trial of 60 health professionals found that Pycnogenol (150 mg/day) may improve cognitive function, attention, mental performance and specific professional skills after 12 weeks. The study provided clear evidence that Pycnogenol does, indeed, offer photoprotection however, it came out even better than expected, showing that it may be used to reduce hyperpigmentation of human skin while improving the skin barrier function and extracellular matrix homeostasis. (6). (2006). 1 Anti-Aging Beverage, Daniel Fast: Benefits for Your Spiritual, Emotional and Physical Health, 15 Fermented Foods for a Healthy Gut and Overall Health, 9 Proven Black Seed Oil Benefits that Boost Your Health, L-Glutamine Benefits Leaky Gut & Metabolism, Chia Seeds Benefits: The Omega-3, Protein-Packed Superfood, Apple Cider Vinegar Benefits for Weight Loss, Skin Health, Cholesterol & More, What Is a Marionberry? . Pycnogenol can help control blood pressure, which helps improve overall heart health. , Allergy: "Leukotriene E4 plasma levels in adult asthmatic patients with variable disease severity. A 2006 study found that children who took a daily pine bark extract supplement for four weeks had significantly lower levels of hyperactivity. . 2005 - 2023 WebMD LLC. Pine bark extract is composed of 80% to 85% proanthocyanidins, the monomers catechin and taxifolin (5%), and phenolic acids, including derivatives of benzoic and cinnamic acids (2% to 4%). Theres some evidence that Pycnogenol acts similar to a sustained-release formulation. Pycnogenol is thought to be an antioxidant that helps protect cells from damage. If youre wondering how to get an even skin tone, there are plenty of remedies that can help. Jonathan Ritter, PharmD, PhD (Pharmacology), Small molecule antioxidants (phenolic acids, catechin, and taxifolin) are quickly absorbed and begin to act in the body within 30 min, The remaining more complex antioxidants (long chains of procyanidins) reach the gut, where your, The microbiome-produced active compounds appear in blood 6 h later and remain for at least 14 h, Pycnogenol is standardized to contain 70 5% procyanidins, which should be on the label, Pycnogenol standardization doesnt determine other major active compounds, which can vary. Work with your pediatrician to see if there are contraindications for each child. Treatment of ADHD with French maritime pine bark extract, Pycnogenol [Abstract]. There are also several other natural ADHD remedies you can try. He later extracted proanthocyanidins from the European coastal pine tree, which he named Pycnogenol.. Lowers Blood Pressure. If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please leave a comment or contact us at [emailprotected]. There is currently insufficient evidence to determine what a safe and effective dose of lysine is for specific conditions. New studies show Pycnogenol can prevent or reverse the oxidative damage that produces blood vessel disease 4, metabolic syndrome 20, diabetes 20,24, and neurodegenerative disorders 23,24. Moreover, Pycnogenol treatment led to an increase in sperm count and testosterone levels with lowering of blood pressure and cholesterol levels. Sign Up for the Latest Health News and Tips, Home Food and Nutrition Pycnogenol (French Maritime Pine Bark Extract): 12 Benefits According to Studies.